Unique patient-relevant models

HUB Organoids® are developed directly from patient material thanks to our exclusive IP-protected technology that allows adult stem cells (ASCs) present in most epithelial tissues to replicate and differentiate in vitro giving rise to functional “mini-organs in a dish”.

infographic-01-white-technology.png

Applications

  • In vitro disease modelling: capture disease relevance and heterogeneity of the patient population
  • Drug discovery and development: test drug efficacy and investigate your compound´s mechanism of action
  • Clinical Trials in a Dish (CTiD): derisk and expedite your therapeutic development with translational models that can be used to identify your target patient population before entering the clinic
  • Companion diagnostics: identify predictive biomarkers of therapeutic outcome using models that recapitulate original patient pathophysiology
  • Safety and toxicity: evaluate your compound´s safety and toxicity profiles with the only patient-derived in vitro model that can be developed from non-transformed cells residing in healthy epithelia
  • Personalized medicine: leverage HUB Organoids™ as patient avatars to design targeted and personalized therapies and stratify your patient population.

Key features of HUB Organoids®

HUB Organoids are innovative models derived directly from adult stem cells (ASC) present in all epithelial organs. This is an important distinction which sets HUB Organoids apart from other patient-derived 3D in vitro systems or other organoid technologies using pluripotent stem cells (iPSC) or embryonic stem cell (ESC).

HUB Organoids are:

  • Clinically-relevant: derived directly from patient tissue, thus recapitulating the pathophysiology of the parental organ in vivo
  • Tissue-specific: highly specialized for their tissue of origin, e.g. colon stem cells can only produce colon organoids
  • Physiologically relevant: encompassing multiple differentiated and functional cellular lineages, allowing to model healthy and diseased tissue biology
  • Genetically and phenotypically stable in long term culture: maintaining parental tissue characteristics indefinitely in culture and after cryopreservation
  • Expandable for large-scale screens
  • Suitable for genetic manipulation as well as most standard in vitro assays
  • Amenable to in vivo modelling via engraftment or xenotransplantation

infographic-02.png

X

Have any questions?

contact us