Innovative technology

Unique patient-relevant models

HUB Organoids^® are developed directly from patient material thanks to our exclusive IP-protected technology that allows adult stem cells (ASCs) present in most epithelial tissues to replicate and differentiate in vitro giving rise to functional “mini-organs in a dish”.

Applications

• In vitro disease modelling: capture disease relevance and heterogeneity of the patient population
• Drug discovery and development: derisk and expedite your therapeutic development with translational models and in vitro drug screening
• Clinical Trials in a Dish (CTiD): stratify your patient populations and customize treatments with models developed from patients enrolled in clinical trials
• Companion diagnostics: identify predictive biomarkers of therapeutic outcome using models that recapitulate original patient pathophysiology
• Safety and toxicity: evaluate your compound´s safety and toxicity profiles with the only patient-derived in vitro model that can be developed from non-transformed cells residing in healthy epithelia
• Personalized medicine: leverage HUB Organoids as patient avatars to design targeted and personalized therapies

Key features of HUB Organoids

HUB Organoids are innovative models derived directly from adult stem cells (ASC) present in all epithelial organs. This is an important distinction which sets HUB Organoids apart from other patient-derived 3D in vitro systems or other organoid technologies using pluripotent stem cells (iPSC) or embryonic stem cell (ESC).

HUB Organoids are:

• Clinically-relevant: derived directly from patient tissue, thus recapitulating the pathophysiology of the parental organ in vivo
• Tissue-specific: highly specialized for their tissue of origin, e.g. colon stem cells can only produce colon organoids
• Physiologically relevant: encompassing multiple differentiated and functional cellular lineages, allowing to model healthy and diseased tissue biology
• Genetically and phenotypically stable in long term culture: maintaining parental tissue characteristics indefinitely in culture and after cryopreservation
• Expandable for large-scale screens
• Suitable for genetic manipulation as well as most standard in vitro assays
• Amenable to in vivo modelling via engraftment or xenotransplantation