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Forskolin-Induced Swelling Assay

The Forskolin-Induced Swelling (FIS) assay is an imaging-based assay that measures organoid swelling as a readout for Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein function before and after treatment to provide indications on a new drug efficacy and patient response. The FIS assay is a valuable tool in Cystic Fibrosis (CF) drug development and patient stratification and has already shown its potential for clinical patient representation and personalized medicine.

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Epithelial barrier function assay

The Transepithelial Electrical Resistance (TEER) assay is designed to analyze tight junction dynamics and determine barrier function integrity of an intestinal epithelium. Organoids are established as a ‘2D’ monolayer in Transwell®.

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Immune-mediated tumor organoid killing assay

We have developed an organoid and immune cell co-culture platform that uses native or engineered immune cells admixed with normal or tumor organoids to evaluate antigen specific recognition/killing of tumor organoids compared to healthy controls. These co-cultures can also be applied to testing new immuno modulatory compounds.

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