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Whereas the CRISPR/Cas9 technology cuts out a defect in a gene and replaces it with a new piece, the latest CRISPR technology works differently. The goal is to repair the error in the DNA without cutting it. Scientists from the research groups of Hans Clevers (Hubrecht Institute) and Jeffrey Beekman (UMC Utrecht) show for the first time that this technique can effectively and safely repair the DNA of organoids derived from cystic fibrosis patients in the lab.